Herald of the Mechnikov Saint-Petersburg State Medical Academy (стр. 14 )

Key words: reproductive system, embriotoxicity, fetotoxicity, antenatal and postnatal development

References:

1.  Морфогенез и эволюция осевого скелета. – Л.: Изд-во «ЛГУ», 1982. - 144 с.

2. , , Ю. Изучение общей токсичности нового лекарственного препарата на основе шалфея и эхинацеи // Сборник научных работ студентов и молодых ученых Всероссийской конференции с международным участием «Актуальные вопросы медицинской науки». - Ярославль: Издательство , 2009. – С. 113-114.

3.  Требования к проведению доклинических токсикологических испытаний ЛС в России. // Фармацевтический вестник. - 2005.- №24. – С 387.

4. Дыбан А. П., Баранов В. С., Акимов И. М. Основные методические подходы к тестированию тератогенной активности химических веществ // Архив анатомии, гистологии и эмбриологии. - 1970. - Т. 59. – С.89–100.

5. , Влияние лекарственных средств на плод. - М., 1990. - 286 c.

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7. Принципы оценки риска для потомства в связи с воздействием химических веществ в период беременности. - Женева. ВОЗ. 1986. – 156 с.

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9. Barnes J., Anderson L. A., Gibbons S., Phillipson J. D. Echinacea species (Echinacea angustifolia (DC.) Hell., Echinacea pallida (Nutt.) Nutt., Echinacea purpurea (L.) Moench): a review of their chemistry, pharmacology and clinical properties. // J. of Pharmacy and Pharmacol. - 2005. – Vol. 57. – P. 929-954.

10. Barrett B. Medicinal properties of Echinacea: A critical review. // Phytomed. - 2003. - Vol. 10. – P. 66-86.

11. Blumental M, Busse W. R., Goldberg A., et al. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. // Boston, MA. American Botanical Council. - 1998. – P. 186-187.

12. Daniel P., Dugoua J., Mills E., Koren G. Safety and efficacy of Echinacea (Echinacea angustifolia, E. purpurea and E. pallida) during pregnancy and lactation. // Can. J. Сlin. Pharmacol. – 2006. – Vol. 13 - N3. - P. 262-267.

13. Elbetieha A., Al-Hamood M. H., Alkofani A., Bataineh H. Reproductive toxicity potencials of Salvia fruticosa (Labiatae) in rats // J. of Ethno-Pharmacol. - 1998. – Vol. 61. - P. 67-74.

14. Gallo M., Sarkar M., Au W., et al. Pregnancy outcome following gestational exposure to Echinacea: a prospective controlled study // Arch. Intern. Med. - 2000. Vol. 160. – P. 3141-3143.

15. ICH harmonised tripartite guideline detection of toxicity to reproduction for medicinal products & toxicity to male fertility S5 (R2). 06.1993.

16. Kholkute S. D., Mudgal V., Deshpande P. J. Screening of indigenous medicinal plants for antifertility potentiality // Planta Medica. - 1976. - Vol. 29. – № 2. – P.151-155.

Information about the authors:

Guseva Svetlana Igorevna – aspirant of the Department of Pharmacology Saint-Petersburg State Medical Academy named after I. I. Mechnikov, tel.: [phone], e-mail: gusya. *****@***ru

Avdeeva Olga Ilyinichna – candidate of pharmaceutical science, senior research officer of the Department of Pharmacology Saint-Petersburg State Medical Academy named after I. I. Mechnikov, tel.: [phone]

Makarova Marina Nikolaevna – candidate of biological science, assistant of the Department of Pharmacology Saint-Petersburg State Medical Academy named after I. I. Mechnikov, deputy of director for science ZAO «Saint-Petersburg Institute of Pharmacy», tel.: [phone], e-mail: *****@***ru

Shikov Alexander Nikolaevich – doctor of pharmacy, professor of the Department of Pharmacology Saint-Petersburg State Medical Academy named after I. I. Mechnikov, deputy of director for science ZAO «Interregional Center «Adaptogen», tel: [phone], e-mail: *****@***ru

Pozharitskaya Olga Nikolaevna – candidate of pharmaceutical science, deputy of director for new technologies ZAO «Saint-Petersburg Institute of Pharmacy», tel.: [phone].

Karachinskaya Irina Viktorovna – 4 year student, medico-prophylactic Department Saint-Petersburg State Medical Academy named after I. I. Mechnikov, tel.: [phone].

Dyachuk Georgy Ivanovich – academic IAELPS, doctor of medicine, professor, head of the Department of Pharmacology Saint-Petersburg State Medical Academy named after I. I. Mechnikov, tel.: [phone].

1266

© E. F.Agletdinov, 2009

UDC 577.158.334.16:[615.9:547.562.33]-092.9

Agletdinov E. F. Glutathione system disorder correction in intoxication with polychlorbiphenils // Herald of the Mechnikov Saint-Petersburg State Medical Academy. – 2009. - № 3 (32). – P. 149-152.

State Educational Establishment of Higher Professional Trainin «Bashkir State Medical University of the Federal Agency for Public Health and Social Development of the Russian Federation», Russia, 450077, Ufa, Lenin str., 3, tel.: [phone], e-mail: *****@***ru

Summary. The effects of polychlorinated biphenyls on testicular glutathione concentration and the activity of glutathione-related enzymes were studied in adult male rats. The results of these experiments show that the action of high doses of PCBs (0.1 LD50) lead to significantly decreasing the activities of glutathione peroxidase and glutathione reductase. The tissue glutathione level also was reduced. These results suggest that revealed disorders may play an important role in pathogenesis of male infertility, caused by environmental pollutants.

Keywords: polychlorinated biphenyls, testis, glutathone.

References:

1.  , и др. Медицина труда и пром. экология. – 2002. - № 5. - С. 16-19.

2.  , , Токсикологический вестник. 1997. № 3. С. 17-23.

3.  , Биологическая роль глутатиона/ Успехи соврем. биологии. 1990. Т. 110, вып. 1(4) . С. 20-33.

4.  , Эколого-аналитический мониторинг стойких органических загрязнителей. – М.: БИНОМ. Лаборатория знаний, 2004.- 323 с.

5.  Патохимические механизмы тестикулярной токсичности стойких органических загрязнителей / , , и др. // Медицинская наука и образование Урала – 2008. - №6 – С. 44-46.

6.  , Свободнорадикальное окисление и антиоксидантная система. Пермь, 1992. 53 с.

7.  , Роль глутатиона в процессах детоксикации/ Вестник АМН СССР. 1988. Т. 1, С. 62-69.

8.  Толстопятова, Г. В. Токсикологическая характеристика полихлорированных бифенилов (обзор литературы) Г. В./ Толстопятова, // Врачебное дело. – 1982. - № 7. – C. 52-60.

9.  Andric SA, Kostic TS, Stojilkovic SS, Kovacevic RZ. Inhibition of rat testicular androgenesis by a polychlorinated biphenyl mixture Aroclor 1248 // Biol. Reprod. – 2000. - 62; 1882-88.

10.  Bessmann A. Accumulation of polychlorinated biphenyls in steroidogenic tissue of gonads and adrenals in Japanese quail. // Arch Environ Contam Toxicol – 1981. - 10: 653-62.

11.  Comhaire F., Mahmoud A., Schoonjans F. Sperm quality, birth rates and the environment in Flanders (Belgium) // Reprod Toxicol. - 2007. – Feb; 23(2):133-7.

12.  Ellman G. L. Tissue sulfhydryl groups. Arch. Biochem. Biophys. 1959. Vol. 82. №1. Р. 70-77

13.  Feshin D. B., Komarova K. A. et al. Bioaccumulation and Distribution of PCBs in Hens and Chickens // Organohalogen compounds, - 2005. - 1498-1501.

14.  Habig W. H., Palst M. J., Jakoby W. B. Glutathione-S-transferase. The first enzymatic step in mercapturic formation. J. Biol. Chem. 1973; 249: Р. 7130-39.

15.  Hauser R, Altshul L. Environmental organochlorines and semen quality: results of a pilot study // Environ Health Perspect - 2002. – Mar; 110(3):229-33.

16.  Orlowski M., Meister A. Isolation of gamma-glutamyl transpeptidase from hog kidney. J. Biol. Chem. 1965;240: Р.338–47.

17.  Rotruck J. K., Pope A. L., Ganther H. E., Swanson A. B., Hafeman D. G., Hoekstra W. G. Selenium: biochemical role as a component of glutathione peroxidase. Science 1973; 179: Р. 588-590.

18.  Stall G. E., Vegel C. Purification and properties of glutathione reductase of human erythrocytes. Biochim Biophys Ada 1969; 185: Р. 39-48.

19.  Toft G, Rignell-Hydbom A. Semen quality and exposure to persistent organochlorine pollutants // Epidemiology. - 2006, - 17(4):450-8.

Information about the author:

Agletdinov Agletdinov Edward Feliksovich - Ph. D. (Medicine), senior teacher of chair of biological and bioorganic chemistry, Bashkir State Medical University, tel. mob. [phone], e-mail: *****@***ru

1176

© S. V. Efremova, 2009

UDC 616.381-089.85:615.211

Efremova S. V. Intraoperative influence of naso-intestinal intubation on endotoxicosis degree in various kinds of anesthesiology // Herald of the Mechnikov Saint-Petersburg State Medical Academy. – 2009. - № 3 (32). – P. 152-155.

State Educational Establishment of Higher Professional Training «Mechnikov Saint-Petersburg State Medical Academy of the Federal Agency for Public Health and Social Development of the Russian Federation», Russia, 195067, St.-Petersburg, К-67, Piskarevsky prospect, 47, tel.: [phone], fax: [phone], e-mail: *****@***com

Summary: Level of low - and medium sized molecules, acid-base balance were studied in 100 patients with acute bowel obstruction. Operations were performed under general anesthesia with nasointestinal intubation. We found that severity of endotoxicosis and metabolic acidosis during nasointestinal intubation does not depend on anesthe­sia technique.