4) Lymphatic drainage

5) Inflammatory reaction

103. The histological nomenclature of tumors is based on which of the following features

1) Stroma component

2) Localization

3) Inflammatory changes

4) Vascular component

5) Parenchymal component histogenesis

104. The term of a benign mesenchymal tumor is constructed by combining the word designating the tumor cell origin plus which of the following endings or words

1) sarcoma

2) carcinoma

3) oma

4) itis

5) osis (-asis)

105. Benign tumor arising from fibroblastic cells is called

1) Chondroma

2) Adenoma

3) Osteoma

4) Fibroma

5) Papilloma

106. Benign tumor arising from the cartilaginous tissue is called

1) Chondroma

2) Adenoma

3) Osteoma

4) Fibroma

5) Papilloma

107. Benign tumor arising from osteoblasts is called

1) Chondroma

2) Adenoma

3) Osteoma

4) Fibroma

5) Papilloma

108. Malignant tumors arising from the mesenchimal tissue are referred to as

1) Sarcomas

2) Adenocarcinomas

3) Papillomas

4) Cystadenomas

5) Polyps

109. The important factors associated with the increasing incidence of tumors are all of the following, EXCEPT

1) Age

2) Diet

3) Environment

4) Acute inflammation

5) Genetic makeup

110. The criteria by which benign tumors can be differentiated from the malignant ones are all of the following, EXCEPT

1) Maturity

2) Rate and character of the growth

3) Localization

4) Anaplasia

5) Metastases

111. Colonic adenocarcinoma metastasizes most commonly to which of the following organs

1) Brain

2) Liver

3) Lung

4) Lymph nodes

5) Spleen

112. Which of the following lesions is a benign tumor

1) Chondroblastic osteosaroma of the bone

2) Granuloma of the soft tissue

3) Tuberculoma

4) Papillary serous cystadenoma of the ovary

5) Papillary carcinoma of the thyroid

113. The most characteristic feature of a malignant tumor is which of the following

1) Capsule

2) Compression of surrounding tissue

3) Large size

4) Necrosis

5) Metastases

114. The most characteristic feature of a malignant neoplasm in contrast to a reactive or inflammatory overgrowth is which of the following

1) Growth factor production

2) Necrosis

3) Localization

4) Autonomous growth

5) Adjacent tissue compression

115. All of the following genes provide the negative control over cell proliferation, EXCEPT

1) p53

2) DCC ("Deleted in Colon Cancer")

3) Rb

4) WT-1

5) bcl-2

116. A tumor that tends to spread over the surfaces of organs or body cavities rather than metastasizing via blood vessels or lymphatics is which of the following

1) Colonic carcinoma

2) Thyroid carcinoma

3) Mesothelioma

4) Renal cell carcinoma

5) Hepatocellular carcinoma

117. Lesion of the female genital tract considered precancerous is which of the following

1) Cystic atrophy of the endometrium

2) Endocervical polyps

3) Condyloma acuminatum of the vulva

4) Endometrial polyps

5) Atypical hyperplasia of the endometrium

118. The important prognostic features in invasive breast cancer are all of the following, EXCEPT

1) Histologic type of the tumor

2) Grade of the tumor

3) Size of the tumor

4) Secondary necrosis

5) Presence or absence of estrogen receptors on tumor cells

119. Carcinomas with epidermoid cell differentiation are called

1) Sarcomas

2) Adenocarcinomas

3) Squamous cell carcinomas

4) Papillomas

5) Cyst adenomas

120. All of the following morphologic features characterize the adenocarcinoma cells, EXCEPT

1) Variation in size and shape

2) Hyperchromatic nuclei

3) Enlarged nucleoli

4) Hypochromatic nuclei

5) Atypical mitoses

121. All of the following are the risk factors for breast cancer, EXCEPT

1) Family history of breast cancer

2) Early menarche

3) Early menopause

4) Oral contraceptive estrogen use

5) Obesity

122. Benign histological lesions that are associated with an increased risk of breast carcinoma include all of the following, EXCEPT

1) Atypical ductal hyperplasia

2) Multiple intraductal papillomas

3) Atypical lobular hyperplasia

4) Apocrine metaplasia

5) Sclerosing adenous

123. Which of the following cells are microscopically found in Paget's disease

1) Foam cells

2) Langhans' giant cells

3) Malignant epithelioid cells

4) Schwann cells

5) Malignant cells in epidermis

124. Gastric carcinoma development is commonly associated with all of the following pathologic conditions, EXCEPT

1) Chronic gastritis

2) HBV-infection

3) Infection by Helicobacter pylori

4) Partial gastrectomy

5) Gastric adenomas

125. Metastases of gastric carcinoma in which of the following organs are referred to as Krukenberg's tumor

1) Liver

2) Lungs

3) Brain

4) Ovaries

5) Kidneys

126. Which of the following is Pancoast tumors

1) Apical lung cancer

2) Tumor of the gastric pylorus

3) Tumor of the mediastinum

4) Pleural tumor

5) Tubular carcinoma of the female breast

127. Carcinoid syndrome results from production of which of the following substances

1) Melanin

2) Serotonin

3) Bilirubin

4) Ferritin

5) Hemosiderin

128. Systemic manifestations (paraneoplastic syndrome) of bronchogenic carcinoma include all of the following, EXCEPT

1) Lambert-Eaton myasthenic syndrome

2) Peripheral neuropathy

3) Goodpasture's syndrome

4) Dermatological abnormalities

5) Lukemoid reactions

129. The most common location of gastric carcinoma is which of the following

1) Cardia

2) Body and fundus

3) Pylorus and antrum

4) Lesser curvature

5) Greater curvature

130. Obstruction of airways in lung tumors may lead tumors may lead to all of following changes, EXCEPT

1) Pneumonia

2) Abscess

3) Calcification

4) Lobar collapse

5) Atelectasis

131. All of the following statements correctly describe nodular non-Hodgkin's lymphomas, EXCEPT

1) They are often associated with a predictable chromosomal translocation

2) They have a better prognosis than diffuse lymphomas

3) They are characterized by cells with irregular nuclear contours

4) They are always composed of neoplastic В cells

5) They are highly responsive to chemotherapy

132. All of the following features are characteristic of myeloid metaplasia with myelofibrosis, EXCEPT

1) Clone proliferation of marrow fibroblasts

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